Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p007 | Uterus | WCRB2014

Oestrogen-driven changes in the bovine uterus are associated with activation of the unfolded protein response

Alfattah Mohammed A , McGettigan Paul Anthony , Browne John Arthur , Alkhodair Khalid M , Pluta Katarzyna , Gallagher Mary E , Reid Colm J , Carrington Stephen D , Evans Alexander C O , Irwin Jane Ann

The endometrium plays a central role in fertility and pregnancy. It undergoes changes in function and histological morphology over the oestrus cycle, driven by dynamic changes in progesterone and oestrogen. To understand the changes resulting from elevated oestrogen levels around oestrus, we profiled the transcriptome of the bovine uterus. Endometrial tissue was collected from synchronized beef heifers in six cohorts: i) 12 h after controlled intravaginal progesterone-releasin...